Generic equivalent of Caspofungin Acetate
1 SKUs available · Available to order · NABP accredited · DSCSA compliant
Caspofungin acetate is the generic equivalent of the brand-name drug Caspofungin Acetate. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Caspofungin acetate through Premier Pharma with same-day fulfillment on in-stock SKUs.
1 INDICATIONS & USAGE Caspofungin acetate for injection is an echinocandin antifungal indicated in adults and pediatric patients (3 months of age and older) for: • Empirical therapy for presumed fungal infections in febrile, neutropenic patients. • Treatment of candidemia and the following Candida infections: intra- abdominal abscesses, peritonitis and pleural space infections. • Treatment of esophageal candidiasis. • Treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies. 1.1 Empirical Therapy for Presumed Fungal Infections in Febrile, Neutropenic Patients Caspofungin acetate for injection is indicated as empirical therapy for presumed fungal…
12.1 Mechanism of Action Caspofungin is an echinocandin antifungal drug [see Microbiology (12.4)].
12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Caspofungin is an echinocandin antifungal drug [see Microbiology (12.4)]. 12.3 Pharmacokinetics Adult and pediatric pharmacokinetic parameters are presented in Table 8. Distribution Plasma concentrations of caspofungin decline in a polyphasic manner following single 1-hour IV infusions. A short α-phase occurs immediately postinfusion, followed by a β-phase (half-life of 9 to 11 hours) that characterizes much of the profile and exhibits clear log-linear behavior from 6 to 48 hours postdose during which the plasma concentration decreases 10-fold. An additional, longer half-life phase, γ-phase, (half-life of 40-50 hours), also occurs. Distributi…
4 CONTRAINDICATIONS Caspofungin is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product [see Adverse Reactions (6)]. • Caspofungin is contraindicated in patients with hypersensitivity to any component of this product.
6 ADVERSE REACTIONS The following serious adverse reactions are discussed in detail in another section of the labeling: • Hypersensitivity [see Warnings and Precautions (5.1)] • Hepatic Effects [see Warnings and Precautions (5.2)] • Elevated Liver Enzymes During Concomitant Use with Cyclosporine [ see Warnings and Precautions (5.3 )] • Adults: Most common adverse reactions (incidence 10% or greater) are diarrhea, pyrexia, ALT/AST increased, blood alkaline phosphatase increased, and blood potassi…
7 DRUG INTERACTIONS Cyclosporine : In two adult clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of caspofungin . Caspofungin did not increase the plasma levels of cyclosporine. There were transient increases in liver ALT and AST when caspofungin and cyclosporine were co-administered.Monitor patients who develop abnormal liver enzymes during concomitant therapy and evaluate the risk/benefit of continuing therapy [see Warnings and Precautions (5.2) and Clin…
2 DOSAGE & ADMINISTRATION Important Administration Instructions For All Patients (2.1): • Administer by slow intravenous (IV) infusion over approximately 1 hour. Do not administer by IV bolus administration. • Do not mix or co-infuse caspofungin acetate for injection with other medications. Do not use diluents containing dextrose (α-D-glucose). Dosage in Adults [18 years of age and older] (2.2): • Administer a single 70-mg loading dose on Day 1, followed by 50 mg once daily for all indications e…
17 PATIENT COUNSELING INFORMATION Hypersensitivity Inform patients that anaphylactic reactions have been reported during administration of caspofungin. Caspofungin can cause hypersensitivity reactions, including rash, facial swelling, angioedema, pruritus, sensation of warmth, or bronchospasm. Inform patients to report these signs or symptoms to their healthcare providers. Hepatic Effects Inform patients that there have been isolated reports of serious hepatic effects from caspofungin therapy. Use in Pregnancy and Breastfeeding Mothers Advise female patients of the potential risks to a fetus.…
Source: FDA. For professional use only. Not a substitute for prescribing information.
| Name | Status |
|---|---|
| CASPOFUNGIN ACETATE FOR INJECTION | 2-Day |
Premier Pharma stocks 1 Caspofungin acetate SKUs — 0 currently in stock — available to licensed pharmacies, clinics, doctor's offices, and veterinary practices. Caspofungin acetate is the generic equivalent of Caspofungin Acetate. Create a free account to see live wholesale pricing and place orders with same-day fulfillment for in-stock items.
Premier Pharma carries Caspofungin acetate in 5 mg/mL and INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION.
12.1 Mechanism of Action Caspofungin is an echinocandin antifungal drug [see Microbiology (12.4)].
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