Generic equivalent of Mexiletine Hydrochloride
3 SKUs available · Available to order · NABP accredited · DSCSA compliant
Mexiletine hydrochloride is the generic equivalent of the brand-name drug Mexiletine Hydrochloride. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Mexiletine hydrochloride through Premier Pharma with same-day fulfillment on in-stock SKUs.
INDICATIONS AND USAGE Mexiletine Hydrochloride Capsules USP are indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life- threatening. Because of the proarrhythmic effects of mexiletine, its use with lesser arrhythmias is generally not recommended. Treatment of patients with asymptomatic ventricular premature contractions should be avoided. Initiation of mexiletine treatment, as with other antiarrhythmic agents used to treat life-threatening arrhythmias, should be carried out in the hospital. Antiarrhythmic drugs have not been shown to enhance survival in patients with ventricular arrhythmia…
WARNINGS BOXED WARNING WARNINGS Mortality In the National Heart, Lung and Blood Institute’s Cardiac Arrhythmia Suppression Trial (CAST), a long-term, multicentered, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction more than six days but less than two years previously, an excessive mortality or non-fatal cardiac arrest rate (7.7%) was seen in patients treated with encainide or flecainide compared with that se…
ADVERSE REACTIONS Mexiletine hydrochloride commonly produces reversible gastrointestinal and nervous system adverse reactions but is otherwise well tolerated. Mexiletine has been evaluated in 483 patients in one month and three month controlled studies and in over 10,000 patients in a large compassionate use program. Dosages in the controlled studies ranged from 600 to 1200 mg/day; some patients (8%) in the compassionate use program were treated with higher daily doses (1600 to 3200 mg/day). In…
Drug Interactions Since mexiletine hydrochloride is a substrate for the metabolic pathways involving CYP2D6 and CYP1A2 enzymes, inhibition or induction of either of these enzymes would be expected to alter mexiletine plasma concentrations. In a formal, single-dose interaction study (n = 6 males) the clearance of mexiletine was decreased by 38% following the coadministration of fluvoxamine, an inhibitor of CYP1A2. In another formal study (n = 8 extensive and n = 7 poor metabolizers of CYP2D6), co…
DOSAGE AND ADMINISTRATION The dosage of mexiletine hydrochloride must be individualized on the basis of response and tolerance, both of which are dose-related. Administration with food or antacid is recommended. Initiate mexiletine therapy with 200 mg every eight hours when rapid control of arrhythmia is not essential. A minimum of two to three days between dose adjustments is recommended. Dose may be adjusted in 50 or 100 mg increments up or down. As with any antiarrhythmic drug, clinical and e…
Source: FDA. For professional use only. Not a substitute for prescribing information.
| Name | Status |
|---|---|
| MEXILETINE HCL 150 MG 100 CAP | 2-Day |
| MEXILETINE HCL 200 MG 100 CAP | 2-Day |
| MEXILETINE HCL 250 MG 100 CAP | 2-Day |
Premier Pharma stocks 3 Mexiletine hydrochloride SKUs — 0 currently in stock — available to licensed pharmacies, clinics, doctor's offices, and veterinary practices. Mexiletine hydrochloride is the generic equivalent of Mexiletine Hydrochloride. Create a free account to see live wholesale pricing and place orders with same-day fulfillment for in-stock items.
Premier Pharma carries Mexiletine hydrochloride in 150 mg/1, 200 mg/1, 250 mg/1 and CAPSULE.
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