Generic equivalent of Phenylephrine Hydrochloride
6 SKUs available · Available to order · NABP accredited · DSCSA compliant
Phenylephrine hydrochloride is the generic equivalent of the brand-name drug Phenylephrine Hydrochloride. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Phenylephrine hydrochloride through Premier Pharma with same-day fulfillment on in-stock SKUs.
1 INDICATIONS AND USAGE Phenylephrine Hydrochloride Injection 10 mg/mL is indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation in the settings of anesthesia and septic shock. Phenylephrine Hydrochloride Injection 10 mg/mL is alpha-1 adrenergic receptor agonist indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation in the settings of anesthesia and septic shock.
12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Phenylephrine hydrochloride is an α-1 adrenergic receptor agonist. 12.2 Pharmacodynamics Phenylephrine is the active moiety. Metabolites are inactive at both the α-1and α-2 adrenergic receptors. Following parenteral administration of phenylephrine hydrochloride, increases in systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, and total peripheral vascular resistance are observed. The onset of blood pressure increase following an intravenous bolus phenylephrine hydrochloride administration is rapid and the effect may persist for up to 20 minutes. As mean arterial pressure increases following parenteral doses, vagal…
4 CONTRAINDICATIONS The use of Phenylephrine Hydrochloride Injection 10 mg/mL is contraindicated in patients with: Hypersensitivity to the products or any of their components Hypersensitivity to the products or any of their components ( 4 )
6 ADVERSE REACTIONS The following adverse reactions associated with the use of phenylephrine hydrochloride were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure. Cardiac disorders : Bradycardia, AV block, ventricular extrasystoles, myocardial ischemia Gastrointestinal disorders : Nausea, vomiting General disorders…
7 DRUG INTERACTIONS Agonistic effects with monoamine oxidase inhibitors (MAOI), β- adrenergic blocking agents, α-2 adrenergic agonists, steroids, tricyclic antidepressants, norepinephrine transport inhibitors, ergot alkaloids, centrally-acting sympatholytic agents and atropine sulfate ( 7.1 ) Antagonistic effects on and by α-adrenergic blocking agents ( 7.2 ) 7.1 Agonists The pressor effect of phenylephrine hydrochloride is increased in patients receiving: Monoamine oxidase inhibitors (MAOI), su…
2 DOSAGE AND ADMINISTRATION Phenylephrine Hydrochloride Injection 10 mg/mL: MUST BE DILUTED before administration. ( 2.1 ) Dosing for Perioperative Hypotension - Intravenous bolus administration: 50 mcg to 250 mcg ( 2.2 ) - Intravenous continuous infusion: 0.5 mcg/kg/minute to 1.4 mcg/kg/minute titrated to effect ( 2.2 ) Dosing for Patients with Vasodilatory Shock - Intravenous continuous infusion: 0.5 mcg/kg/minute to 6 mcg/kg/minute titrated to effect ( 2.2 ) 2.1 General Administration Instruc…
17 PATIENT COUNSELING INFORMATION Inform patients, families, or caregivers that the primary side effect of phenylephrine is hypertension and, rarely, hypertensive crisis. Patients may experience bradycardia (slow heart rate), which in some cases may produce heart block or other cardiac arrhythmias, extra ventricular beats, myocardial ischemia in patients with underlying cardiac disease, and pulmonary edema (fluid in the lungs) or rales. Common, less serious symptoms include the following: chest pain skin or tissue damage if the drug leaks out of the venous catheter into the surrounding tissue…
Source: FDA. For professional use only. Not a substitute for prescribing information.
| Name | Status |
|---|---|
| PHENYLEPHRINE HCL INJ 10MG/ML 25X1ML | 2-Day |
| PHENYLEPHRINE HCL INJ 10MG/ML 25X1ML | 2-Day |
| PHENYLEPHRINE HCL INJ 50ML/5ML 10X5ML VIALS | 2-Day |
| PHENYLEPHRINE HCL INJECTION 10MG/ML 1ML | 2-Day |
| PHENYLEPHRINE HCL 2.5%-ML O/S 10 ML Paragon BioTeck, Inc. | 2-Day |
| PHENYLEPHRINE OPTH SOL 2.5% 15ML | 2-Day |
Premier Pharma stocks 6 Phenylephrine hydrochloride SKUs — 0 currently in stock — available to licensed pharmacies, clinics, doctor's offices, and veterinary practices. Phenylephrine hydrochloride is the generic equivalent of Phenylephrine Hydrochloride. Create a free account to see live wholesale pricing and place orders with same-day fulfillment for in-stock items.
Premier Pharma carries Phenylephrine hydrochloride in 10 mg/mL, 25 mg/mL and INJECTION, INJECTION, SOLUTION, SOLUTION/ DROPS. Available from manufacturers including Paragon BioTeck, Inc..
Phenylephrine hydrochloride carries an FDA Orange Book TE code of AT. Therapeutically equivalent — topical product. Always verify substitution with the current Orange Book before dispensing.
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