Generic equivalent of ROCURONIUM BROMIDE
3 SKUs available · In stock · NABP accredited · DSCSA compliant
Rocuronium bromide is the generic equivalent of the brand-name drug ROCURONIUM BROMIDE. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Rocuronium bromide through Premier Pharma with same-day fulfillment on in-stock SKUs.
1 INDICATIONS AND USAGE Rocuronium bromide Injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Rocuronium bromide is a nondepolarizing neuromuscular blocking agent indicated as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. (1)
12.1 Mechanism of Action Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. 12.2 Pharmacodynamics The ED 95 (dose required to produce 95% suppression of the first [T 1 ] mechanomyographic [MMG] response of the adductor pollicis muscle [thumb] to indirect supramaximal train-of-four stimulation of the ulnar nerve) during opioid/nitrous oxide/oxygen anesthesia is approximately 0.3 mg/kg. Patient variabilit…
4 CONTRAINDICATIONS Rocuronium bromide injection is contraindicated in patients known to have hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents [see Warnings and Precautions (5.2) ]. Hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents. (4)
6 ADVERSE REACTIONS In clinical trials, the most common adverse reactions (2%) are transient hypotension and hypertension. The following adverse reactions are described, or described in greater detail, in other sections: Anaphylaxis [see Warnings and Precautions (5.2 )] Residual paralysis [see Warnings and Precautions (5. 5)] Myopathy [see Warnings and Precautions (5.6) ] Increased pulmonary vascular resistance [see Warnings and Precautions (5.12) ] Most common adverse reactions (2%) are transie…
7 DRUG INTERACTIONS Succinylcholine: Use before succinylcholine has not been studied. (7.11) Nondepolarizing muscle relaxants: Interactions have been observed. (7.7) Enhanced Rocuronium Bromide Injection activity possible: Inhalation anesthetics (7.3), certain antibiotics (7.1), quinidine (7.10), magnesium (7.6), lithium (7.4), local anesthetics (7.5), procainamide (7.8) Reduced rocuronium bromide activity possible: Anticonvulsants. (7.2) 7.1 Antibiotics Drugs which may enhance the neuromuscular…
2 DOSAGE AND ADMINISTRATION To be administered only by experienced clinicians or adequately trained individuals supervised by an experienced clinician familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents. (2.1) • Individualize the dose for each patient. (2.1) • Peripheral nerve stimulator recommended for determination of drug response and need for additional doses, and to evaluate recovery. (2.1) • Store Rocuronium bromide Injection with cap and fer…
17 PATIENT COUNSELING INFORMATION Obtain information about your patient's medical history, current medications, any history of hypersensitivity to rocuronium bromide or other neuromuscular blocking agents. If applicable, inform your patients that certain medical conditions and medications might influence how rocuronium bromide works. In addition, inform your patient that severe anaphylactic reactions to neuromuscular blocking agents, including rocuronium bromide, have been reported. Since allergic cross-reactivity has been reported in this class, request information from your patients about pr…
Source: FDA. For professional use only. Not a substitute for prescribing information.
| Name | Status |
|---|---|
| ROCURONIUM INJ 50MG/ML 10X5ML VIAL | In Stock |
| ROCURONIUM 100MG MDV 10X10ML | 2-Day |
| ROCURONIUM BROMIDE 10MG/ML 10X5ML VIALS XGen Pharmaceuticals DJB, Inc. | 2-Day |
Premier Pharma stocks 3 Rocuronium bromide SKUs — 1 currently in stock — available to licensed pharmacies, clinics, doctor's offices, and veterinary practices. Rocuronium bromide is the generic equivalent of ROCURONIUM BROMIDE. Create a free account to see live wholesale pricing and place orders with same-day fulfillment for in-stock items.
Premier Pharma carries Rocuronium bromide in 10 mg/mL and INJECTION, INJECTION, SOLUTION, SOLUTION. Available from manufacturers including XGen Pharmaceuticals DJB, Inc..
Rocuronium bromide carries an FDA Orange Book TE code of AP. Therapeutically equivalent — injectable aqueous solution. Always verify substitution with the current Orange Book before dispensing.
12.1 Mechanism of Action Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.
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