Generic equivalent of Sugammadex
1 SKUs available · Available to order · NABP accredited · DSCSA compliant
Sugammadex is the generic equivalent of the brand-name drug Sugammadex. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Sugammadex through Premier Pharma with same-day fulfillment on in-stock SKUs.
1 INDICATIONS AND USAGE Sugammadex injection is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adult and pediatric patients aged 2 years and older undergoing surgery. Additional pediatric use information is approved for Merck Sharp & Dohme LLC's BRIDION ® (sugammadex) injection. However, due to Merck Sharp & Dohme LLC's marketing exclusivity rights, this drug product is not labeled with that information. Sugammadex injection is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adult and pediatric patients aged 2 years and older undergoing surgery. ( 1 )
12.1 Mechanism of Action Sugammadex is a modified gamma cyclodextrin. It forms a complex with the neuromuscular blocking agents rocuronium and vecuronium, and it reduces the amount of neuromuscular blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction. This results in the reversal of neuromuscular blockade induced by rocuronium and vecuronium.
12 CLINICAL PHARMACOLOGY 12.1 Mechanism of Action Sugammadex is a modified gamma cyclodextrin. It forms a complex with the neuromuscular blocking agents rocuronium and vecuronium, and it reduces the amount of neuromuscular blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction. This results in the reversal of neuromuscular blockade induced by rocuronium and vecuronium. 12.2 Pharmacodynamics Sugammadex has been administered in doses ranging from 0.5 mg/kg to 16 mg/kg in dose response trials of rocuronium-induced blockade (0.6, 0.9, 1 and 1.2 mg/kg with and without maintenance doses) and vecuronium-induced blockade (0.1 mg/kg with or without maintenan…
4 CONTRAINDICATIONS Sugammadex is contraindicated in patients with known hypersensitivity to sugammadex or any of its components. Hypersensitivity reactions that occurred varied from isolated skin reactions to serious systemic reactions (i.e., anaphylaxis, anaphylactic shock) and have occurred in patients with no prior exposure to sugammadex [see Warnings and Precautions (5.1 ), Adverse Reactions (6) ]. Known hypersensitivity to sugammadex or any of its components. ( 4 )
6 ADVERSE REACTIONS The following serious adverse reactions are described elsewhere in the labeling: • Anaphylaxis and Hypersensitivity [see Contraindications (4), Warnings and Precautions (5.1) ] • Marked Bradycardia [see Warnings and Precautions (5.2) ] • Most common adverse reactions (reported in ≥10% of adult patients at a 2, 4, or 16 mg/kg sugammadex dose and higher than the placebo rate): vomiting, pain, nausea, hypotension, and headache. ( 6.1 ) • Most common adverse reactions (reported i…
7 DRUG INTERACTIONS Toremifene : Concomitant use can delay recovery. ( 7.2 ) Hormonal contraceptives : Patients must use an additional, non-hormonal method of contraception for 7 days following sugammadex administration. ( 5.6 , 7.3 ) 7.1 Summary The information reported in sections 7.2 to 7.4 is based on binding affinity between sugammadex and other drugs, preclinical experiments, clinical studies and simulations of a pharmacokinetic-pharmacodynamic (PK-PD) model. Based on these considerations,…
2 DOSAGE AND ADMINISTRATION • Dosing is based on actual body weight ( 2.1 ) • Monitor for twitch responses to determine the timing and dose for sugammadex injection administration. ( 2.1 ) • Administer as a single bolus injection. ( 2.1 ) For rocuronium and vecuronium: • 4 mg/kg is recommended if spontaneous recovery of the twitch response has reached 1 to 2 post-tetanic counts (PTC) and there are no twitch responses to train-of-four (TOF) stimulation. ( 2.2 ) • 2 mg/kg is recommended if spontan…
17 PATIENT COUNSELING INFORMATION • Advise females of reproductive potential using hormonal contraceptives that sugammadex injection may reduce the contraceptive effect. Instruct females to use an additional, non-hormonal method of contraception for the next 7 days following sugammadex injection administration [see Drug Interactions (7.3) ]. Manufactured for: Camber Pharmaceuticals, Inc., Piscataway, NJ 08854. Manufactured by: Aspiro Pharma Limited Survey No. 321, Biotech Park, Phase – III Karkapatla Village, Markook (Mandal) Siddipet, Telangana-502281, India. Issued:04/2026 camberlabel aspiro…
Source: FDA. For professional use only. Not a substitute for prescribing information.
| Name | Status |
|---|---|
| SUGAMMADEX 200MG/2ML 10X2ML VIALS | 2-Day |
Premier Pharma stocks 1 Sugammadex SKUs — 0 currently in stock — available to licensed pharmacies, clinics, doctor's offices, and veterinary practices. Sugammadex is the generic equivalent of Sugammadex. Create a free account to see live wholesale pricing and place orders with same-day fulfillment for in-stock items.
Premier Pharma carries Sugammadex in 100 mg/mL and INJECTION.
12.1 Mechanism of Action Sugammadex is a modified gamma cyclodextrin. It forms a complex with the neuromuscular blocking agents rocuronium and vecuronium, and it reduces the amount of neuromuscular blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction. This results in the reversal of neuromuscular blockade induced by rocuronium and vecuronium.
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