Carbidopa and levodopa is the generic equivalent of the brand-name drug CARBIDOPA AND LEVODOPA. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Carbidopa and levodopa through Premier Pharma with same-day fulfillment on in-stock SKUs.
Available Strengths
10 mg/1, 100 mg/125 mg/1, 100 mg/125 mg/1, 250 mg/150 mg/1, 200 mg/161.25 mg/1, 245 mg/1
Dosage Forms
CAPSULE, EXTENDED RELEASETABLETTABLET, EXTENDED RELEASETABLET, ORALLY DISINTEGRATING
FDA Drug Information
Indications & Usage
INDICATIONS AND USAGE Carbidopa and levodopa orally disintegrating tablets are indicated in the treatment of Parkinson’s disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide intoxication or manganese intoxication. Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopa. Some patients who responded poorly to levodopa have improved on carbidopa and levodopa orally disintegrating tablets. This is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous system. Carbidopa has not been shown to enhance th…
Important Warnings
WARNINGS When carbidopa and levodopa orally disintegrating tablet is to be given to patients who are being treated with levodopa, levodopa must be discontinued at least twelve hours before therapy with carbidopa and levodopa orally disintegrating tablet is started. In order to reduce adverse reactions, it is necessary to individualize therapy. See DOSAGE AND ADMINISTRATION section before initiating therapy. The addition of carbidopa with levodopa in the form of carbidopa and levodopa orally disi…
Adverse Reactions
ADVERSE REACTIONS The most common adverse reactions reported with carbidopa and levodopa have included dyskinesias, such as choreiform, dystonic, and other involuntary movements, and nausea. The following other adverse reactions have been reported with carbidopa and levodopa: Body as a Whole: chest pain, asthenia. Cardiovascular: cardiac irregularities, hypotension, orthostatic effects including orthostatic hypotension, hypertension, syncope, phlebitis, palpitation. Gastrointestinal: dark saliva…
Drug Interactions
Drug Interactions Caution should be exercised when the following drugs are administered concomitantly with carbidopa and levodopa orally disintegrating tablets. Symptomatic postural hypotension occurred when carbidopa and levodopa was added to the treatment of a patient receiving antihypertensive drugs. Therefore, when therapy with carbidopa and levodopa orally disintegrating tablets is started, dosage adjustment of the antihypertensive drug may be required. For patients receiving MAO inhibitors…
Dosage & Administration
DOSAGE AND ADMINISTRATION Instructions for Use/Handling Carbidopa and Levodopa Orally Disintegrating Tablets, USP Just prior to administration, GENTLY remove the tablet from the bottle with dry hands. IMMEDIATELY place the carbidopa and levodopa orally disintegrating tablet on top of the tongue where it will dissolve in seconds, then swallow with saliva. Administration with liquid is not necessary. The optimum daily dosage of carbidopa and levodopa orally disintegrating tablets must be determine…
Patient Counseling Information
Information for Patients Phenylketonurics Phenylketonuric patients should be informed that carbidopa and levodopa orally disintegrating tablet contains phenylalanine 1.6 mg per 25 mg/100 mg orally disintegrating tablet, 1.6 mg per 10 mg/100 mg orally disintegrating tablet, and 4 mg per 25 mg/250 mg orally disintegrating tablet. Patients should be instructed not to remove carbidopa and levodopa orally disintegrating tablets from the bottle until just prior to dosing. With dry hands, the tablet should be gently removed and immediately placed on the tongue to dissolve and be swallowed with the sa…
Source: FDA. For professional use only. Not a substitute for prescribing information.
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