Generic equivalent of Childrens Benadryl DYE-FREE ALLERGY, DIPHENHYDRAMINE, Diphenhydramine Hydrochloride, M-Dryl
4 SKUs available · In stock · NABP accredited · DSCSA compliant
Diphenhydramine hydrochloride is the generic equivalent of the brand-name drug Childrens Benadryl DYE-FREE ALLERGY, DIPHENHYDRAMINE, Diphenhydramine Hydrochloride, M-Dryl. Licensed pharmacies, clinics, doctor's offices, and veterinary practices can source wholesale Diphenhydramine hydrochloride through Premier Pharma with same-day fulfillment on in-stock SKUs.
INDICATIONS AND USAGE Diphenhydramine hydrochloride in the injectable form is effective in adults and pediatric patients, other than premature infants and neonates, for the following conditions when diphenhydramine hydrochloride in the oral form is impractical. Antihistaminic For amelioration of allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine and other standard measures after the acute symptoms have been controlled, and for other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated. Motion sickness For active treatment of motion sickness. Antiparkinsonism For use in parkinsonism, when oral therapy is imp…
CLINICAL PHARMACOLOGY Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. Detailed information on the pharmacokinetics of Diphenhydramine Hydrochloride Injection is not available.
CONTRAINDICATIONS Use in Neonates or Premature Infants This drug should not be used in neonates or premature infants. Use in Nursing Mothers Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers. Use as a Local Anesthetic Because of the risk of local necrosis, this drug should not be used as a local anesthetic. Antihistamines are also contraindicated in the following conditions Hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical str…
ADVERSE REACTIONS The most frequent adverse reactions are underscored. 1. General: Urticaria, drug rash, anaphylactic shock, photosensitivity, excessive perspiration, chills, dryness of mouth, nose, and throat. 2. Cardiovascular System: Hypotension, headache, palpitations, tachycardia, extrasystoles. 3. Hematologic System: Hemolytic anemia, thrombocytopenia, agranulocytosis. 4. Nervous System: Sedation, sleepiness, dizziness, disturbed coordination , fatigue, confusion, restlessness, excitation,…
Drug Interactions Diphenhydramine hydrochloride has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc). MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines.
DOSAGE AND ADMINISTRATION THIS PRODUCT IS FOR INTRAVENOUS OR INTRAMUSCULAR ADMINISTRATION ONLY. Diphenhydramine hydrochloride in the injectable form is indicated when the oral form is impractical. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT. Pediatric Patients, other than premature infants and ne…
Information for Patients Patients taking diphenhydramine hydrochloride should be advised that this drug may cause drowsiness and has an additive effect with alcohol. Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating appliances, machinery, etc.
Source: FDA. For professional use only. Not a substitute for prescribing information.
Premier Pharma stocks 4 Diphenhydramine hydrochloride SKUs — 1 currently in stock — available to licensed pharmacies, clinics, doctor's offices, and veterinary practices. Diphenhydramine hydrochloride is the generic equivalent of Childrens Benadryl DYE-FREE ALLERGY. Create a free account to see live wholesale pricing and place orders with same-day fulfillment for in-stock items.
Premier Pharma carries Diphenhydramine hydrochloride in 12.5 mg/5mL, 50 mg/mL and INJECTION, SOLUTION, LIQUID, SOLUTION.
Diphenhydramine hydrochloride carries an FDA Orange Book TE code of AP. Therapeutically equivalent — injectable aqueous solution. Always verify substitution with the current Orange Book before dispensing.
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