Progesterone injection USP is 50 mg/mL in sesame oil with benzyl alcohol, sold in 10 mL multiple-dose vials for intramuscular use only. Sesame sensitivity is a labeled contraindication. Here's what's on the label and how to stock it.
· 3 min read
Written and clinically reviewed by Jacob Fuchs, PharmD
Reviewed on
NDC: 55150-0306-10
In stockProgesterone injection USP, what everyone calls "progesterone in oil," is 50 mg/mL of progesterone in sesame oil, with benzyl alcohol as a preservative. It comes in a 10 mL multiple-dose vial and is labeled for intramuscular use only (Eugia label). Sensitivity to sesame oil or seeds is a labeled contraindication.
It's a simple product to stock. The two things that trip clinics up are the oil and the 28-day clock.
From Eugia's labeling (label; package and storage):
The labeled indications are amenorrhea and abnormal uterine bleeding due to hormonal imbalance, in the absence of organic pathology such as submucous fibroids or uterine cancer (Eugia label). Fertility practices also stock it. How it's used is a prescriber decision.
The labeled contraindications include (Eugia label):
That last one is why the vehicle matters. If a patient can't have sesame, this product isn't a simple swap. That's a conversation for the prescriber and the pharmacist.
It's a multiple-dose vial, so once it's opened, CDC's rule applies: date it and discard it within 28 days unless the manufacturer states another date (CDC). Write the discard date on it, not the date you opened it (The Joint Commission).
For a clinic that gives a few injections a week from a 10 mL vial, the 28-day clock can run out before the vial does. Count your real use per opened vial before you set reorder quantities. More in our single-dose vs. multiple-dose vials guide.
Eugia's label says store at 20°C to 25°C (68°F to 77°F), USP controlled room temperature (label). As with any parenteral, inspect for particles and discoloration before use. It's an oily solution, so look closely.
Premier Pharma supplies licensed fertility clinics, OB/GYN practices, physician offices, and pharmacies, and every invoice lists the lot number and expiration date for each item. We carry progesterone injection USP 50 mg/mL, 10 mL multiple-dose vial (Eugia). Open a free account. Credential review typically takes 1–2 business days.
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